Diabetes-induced loss of gastric ICC accompanied by up-regulation of natriuretic peptide signaling pathways in STZ-induced diabetic mice

► We found that natriuretic peptide (NP) signaling pathway are up-regulated in diabetic gastric smooth muscle of mouse. ► NP/NPR-A, B/cGMP signaling pathway down-regulates mSCF/c-Kit signaling pathway in gastric smooth muscle. ► cANF/NPR-C signaling pathway shows an anti-proliferation effect in cultured gastric smooth muscle cells.