کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8349613 1541803 2018 36 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuropathic Pain models caused by damage to central or peripheral nervous system
ترجمه فارسی عنوان
مدل های درد نوروپاتیک ناشی از آسیب به سیستم عصبی مرکزی یا محیطی
کلمات کلیدی
درد عصبی، هیپرالژیزا، آسیب سیستم عصبی محیطی، نوروپاتی دیابتی، شیمی درمانی ناشی از نوروپاتی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Neuropathic Pain (NP) is a painful condition which is a direct consequence of a lesion or disease affecting the somatosensory system with symptoms like allodynia, hyperalgesia. It has complex pathogenesis as it involves several molecular signaling pathways, thus numerous reliable animal models are crucial to understand the underlying mechanism of NP and formulate effective management therapy. Some models like spinal cord injury, chronic constriction injury, spinal nerve ligation, chemotherapy induced peripheral neuropathy, diabetes-induced NP and many more are discussed. This review contains an overview of the procedures followed to induce neuropathy and specific characteristics of that particular model. Some new techniques like spared nerve ligation, have omitted the limitation of methods not presently used where complete nerve damage occurs. Since animal models provide a window to experienced symptoms and physiology and impact the translation of bench discoveries to the bedside, the reporting, interpretation and comparison of these models is necessary because slight variation in procedure of model generation can drastically alter the results. The development of novel, but rational analgesic drugs to alleviate this intractable pain demands elucidation of molecular mechanisms of NP for which different types of animal models have been established.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 70, Issue 2, April 2018, Pages 206-216
نویسندگان
, , ,