کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8369241 | 1543040 | 2012 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of an in vitro assay system as a potential alternative to current histamine sensitization test for acellular pertussis vaccines
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evaluation of an in vitro assay system as a potential alternative to current histamine sensitization test for acellular pertussis vaccines Evaluation of an in vitro assay system as a potential alternative to current histamine sensitization test for acellular pertussis vaccines](/preview/png/8369241.png)
چکیده انگلیسی
The results showed that the methodology of the E-HPLC and carbohydrate binding assays are transferable between laboratories worldwide and is suitable for the three types of ACV products included in the study. Although direct correlation between the in vitro assay system and the in vivo HIST (temperature reduction assay) for each individual vaccine lot cannot be established due to the large variation in the HIST results, the observation that the mean estimates of the in vitro and in vivo activities gave the same rank order of the three vaccine types included in the study is encouraging. The in vitro systems provide reproducible product specific profiles which supports their use as a potential alternative to the HIST.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biologicals - Volume 40, Issue 6, November 2012, Pages 456-465
Journal: Biologicals - Volume 40, Issue 6, November 2012, Pages 456-465
نویسندگان
Dorothy Xing, Chun-Ting Yuen, Catpagavalli Asokanathan, Peter Rigsby, Yoshinobu Horiuchi,