کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8395728 1544142 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Scorpion venom components as potential candidates for drug development
ترجمه فارسی عنوان
اجزای سم عقرب به عنوان کاندیداهای بالقوه برای توسعه مواد مخدر
کلمات کلیدی
پپتیدهای ضد سرطان، ضد میکروبی، پراکنده شدن پستان برادیکینین، نامزدهای مواد مخدر، مدولاتور ایمنی، زهر عقرب،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
چکیده انگلیسی
Scorpions are well known for their dangerous stings that can result in severe consequences for human beings, including death. Neurotoxins present in their venoms are responsible for their toxicity. Due to their medical relevance, toxins have been the driving force in the scorpion natural compounds research field. On the other hand, for thousands of years, scorpions and their venoms have been applied in traditional medicine, mainly in Asia and Africa. With the remarkable growth in the number of characterized scorpion venom components, several drug candidates have been found with the potential to tackle many of the emerging global medical threats. Scorpions have become a valuable source of biologically active molecules, from novel antibiotics to potential anticancer therapeutics. Other venom components have drawn attention as useful scaffolds for the development of drugs. This review summarizes the most promising candidates for drug development that have been isolated from scorpion venoms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 93, January 2015, Pages 125-135
نویسندگان
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