کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8396818 1544159 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Safety of intravenous equine F(ab')2: Insights following clinical trials involving 1534 recipients of scorpion antivenom
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Safety of intravenous equine F(ab')2: Insights following clinical trials involving 1534 recipients of scorpion antivenom
چکیده انگلیسی
Rates of immune reaction to this product were two orders of magnitude lower than the range (up to 75% for early and 81% for late reactions) historically reported with use of minimally refined whole immunoglobulin products against a variety of infections and envenomations. Lower protein dose, greater purity of the active component, lack of the immunogenic Fc portion of the immunoglobulin molecule, and slow intravenous infusion are likely to be the reason for this. Clinical implications of a safer product include that it can be employed in settings where antivenom was once considered too dangerous to use, such as primary care clinics and remote rural areas.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 76, 15 December 2013, Pages 386-393
نویسندگان
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