Primary structure and characterization of a non hemorrhagic metalloproteinase with fibrinolytic activity, from the snake venom of Protobothrops tokarensis (Tokara-habu)

PT-H2 protease consisted of 201 amino acid residues and had a calculated molecular weight of 22,994.7 Da. This protein showed conservation of the Zn2+-binding HEXXHXXGXXHD sequence. PT-H2 protease showed high homology from 51.7 to 99.5% with amino acid sequences of other snake venom metalloproteinases.