The crucial role of the MyD88 adaptor protein in the inflammatory response induced by Bothrops atrox venom

► MyD88 protein deficiency affects the acute inflammatory events induced by Bothrops atrox venom (BaV). ► MyD88 is required in leukocyte influx induced by BaV peritoneal injection. ► MyD88 signaling is essential in BaV-induced inflammatory cytokines, CCL-2, eicosanoids and COX-2 expression.