Sponge implant in Swiss mice as a model for studying loxoscelism

► We evaluated the viability of the sponge implant model for the study of loxoscelism. ► The sponge implant model induced the formation of a fibrovascular tissue. ► The model mimics the events of cutaneous wound healing similar to a dermal reaction. ► This technique holds potential to determining local events related with loxocelism.