Insights into the local pathogenesis induced by fish toxins: Role of natterins and nattectin in the disruption of cell-cell and cell-extracellular matrix interactions and modulation of cell migration

► Thalassophryne nattereri is venomous fish provoked many accidents in Brazil. ► The venom is composed by proteases natterins and a C-type lectin nattectin. ► Toxins alter the ECM structure, decreasing collagen fiber content. ► Nattectin bind collagens and integrin β1 subunit, improving adhesion and survival. ► Natterins cleave collagens, disrupting cell attachment and induce necrosis.