کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8425090 | 1546023 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion](/preview/png/8425090.png)
چکیده انگلیسی
Astrotactin-2, encoded by ASTN2, is implicated in neuronal migration. Although genetic studies of schizophrenia (SCZ) patients have suggested that exonic deletions of ASTN2 are associated with neurodevelopmental and psychiatric disorders, their biological significance remains unclear. Herein, we generated human induced pluripotent stem cells (iPSCs) from a SCZ patient with an exonic deletion of ASTN2. The generated iPSCs carried ASTN2 deletion and showed typical iPSC morphology, pluripotency marker expression, normal chromosomal aneuploidy, and the capacity to differentiate into three germ layers. This iPSC line may be suitable for evaluating Astrotactin-2 function relevant for SCZ onset in the human brain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Stem Cell Research - Volume 30, July 2018, Pages 81-84
Journal: Stem Cell Research - Volume 30, July 2018, Pages 81-84
نویسندگان
Yuko Arioka, Itaru Kushima, Hisako Kubo, Daisuke Mori, Norio Ozaki,