کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8425559 1546026 2018 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism
چکیده انگلیسی
Turner syndrome (TS) with 45,X/46,XY mosaic karyotype is a rare sex chromosome disorder with an occurrence of 0.15‰ at birth. We report the generation of an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells of a Chinese adult male with 45,X/46,XY mosaicism. The iPSC line retains the original 45,X/46,XY mosaic karyotype, expresses pluripotency markers and undergoes trilineage differentiation. Therefore, it offers an unprecedented cellular model to investigate the profound symptoms like infertility of TS in the male, and serve as a useful tool to develop therapies for the disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Stem Cell Research - Volume 27, March 2018, Pages 42-45
نویسندگان
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