کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8429740 | 1546226 | 2018 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Promising Outcome of Umbilical Cord Blood Transplantation in Patients with Multiple Comorbidities
ترجمه فارسی عنوان
نتایج کلیدی پیوند خون بند ناف در بیماران مبتلا به کمخونی های متعدد
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کلمات کلیدی
شاخص پیوند کلیه سلول هماتوپوئیدی، منبع سلول بنیادی، پیوند خون بند ناف، مرگ و میر غیرقابل برگشت بقای کل،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
The hematopoietic cell transplantation-specific comorbidity index (HCT-CI) has been recently proposed to predict the probability of nonrelapse mortality (NRM) and overall survival (OS) in allogeneic hematopoietic stem cell transplantation (HSCT). However, the usefulness of the HCT-CI in single-unit umbilical cord blood transplantation (UCBT) remains unclear. We investigated the impact of the HCT-CI on the clinical outcomes of allogeneic HSCT in a single-center retrospective study including 53 recipients of UCBT (UCBT group) and 90 recipients of other HSCT (non-UCBT group). In the non-UCBT group 2-year OS rates for HCT-CI score <â3 andââ¥3 were 67% (nâ=â74; 95% confidence interval [CI], 54% to 78%) and 26% (nâ=â16; 95% CI, 7% to 51%), respectively (Pâ=â.001). In the UCBT group these rates were 66% (nâ=â39; 95% CI, 48% to 79%) and 69% (nâ=â14; 95% CI, 36% to 87%), respectively (Pâ=â.73). In the non-UCBT group 1-year NRM rates for HCT-CI score <â3 andââ¥3 were 14% (95% CI, 6.4% to 22%) and 37% (95% CI, 14% to 61%), respectively (Pâ=â.02). In the UCBT group these rates were 6.1% (95% CI, 3.4% to 24%) and 7.7% (95% CI, .4% to 29%), respectively (Pâ=â.78). Using multivariate analysis we showed that HCT-CI score ⥠3 was significantly associated with lower OS (hazard ratio, 3.06; 95% CI, 1.47 to 6.38; Pâ=â.003) and higher NRM (hazard ratio, 2.87; 95% CI, 1.18 to 6.96; Pâ=â.02) for the non-UCBT group. UCBT showed good OS with low incidence of NRM, even in patients with high HCT-CI scores. Altogether, we propose single-unit UCB to be a promising stem cell source for improving survival in patients with multiple comorbidities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biology of Blood and Marrow Transplantation - Volume 24, Issue 7, July 2018, Pages 1455-1462
Journal: Biology of Blood and Marrow Transplantation - Volume 24, Issue 7, July 2018, Pages 1455-1462
نویسندگان
Yoshitaka Adachi, Shun Ukai, Ken Sagou, Nobuaki Fukushima, Kazutaka Ozeki, Akio Kohno,