Increase of Intermediate Monocytes in Graft-versus-Host Disease: Correlation with MDR1+Th17.1 Levels and the Effect of Prednisolone and 1α,25-Dihydroxyvitamin D3

- Intermediate monocytes are increased in patients with GVHD.
- Intermediate monocytes promote the induction of MDR1+Th17.1 cells.
- 1α,25-(OH)2D3 treatment of monocytes reduces prednisolone-induced MDR1+Th17.1 cells.
- JAK2 and CD74 expression is decreased in monocytes treated with 1α,25-(OH)2D3.
- Combination of 1α,25-(OH)2D3 and prednisolone might be promising for GVHD treatment.