کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8431091 | 1546253 | 2016 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of Cumulative Steroid Dose with Risk of Infection after Treatment for Severe Acute Graft-versus-Host Disease
ترجمه فارسی عنوان
انجمن دوز استروئید تجمعی با خطر ابتلا به عفونت پس از درمان برای بیماری شدید حاد گاو در مقابل میزبان
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کلمات کلیدی
بیماری میزبان در مقابل میزبان، عفونت قارچی، پیوند سلول هماتوپوئیت، سیتومگالوویروس، آدنویروس، دوز استروئید،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
This study aimed to characterize the incidence and risk factors of invasive fungal disease, cytomegalovirus infection, other viral diseases, and gram-negative rod infection after glucocorticoid treatment for severe acute graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation and to elucidate the associations of cumulative steroid dose with the risks of individual infections. The study cohort included 91 consecutive patients who developed maximum grades III and IV acute GVHD at our center. The mean cumulative prednisolone-equivalent dose was 41 mg/kg during the first 4 weeks. The cumulative incidence rates of fungal disease, cytomegalovirus disease, other viral diseases, and gram-negative rod infection at 6 months after glucocorticoid treatment were remarkably high, at 14%, 21%, 28%, and 20%, respectively. GVHD within 26 days after transplantation and low lymphocyte count at GVHD treatment were associated with increased risks of several infections. Cumulative prednisolone-equivalent steroid doses ⥠55 mg/kg during the first 4 weeks were associated with an increased risk of fungal disease (hazard ratio, 3.65; P = .03) and cumulative doses â¥Â 23 mg/kg were associated with an increased risk of non-cytomegalovirus viral diseases (hazard ratio, 4.14; P = .02). Strategies to reduce the risk of infectious complications are needed, particularly for patients who have risk factors and those who receive high cumulative steroid doses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biology of Blood and Marrow Transplantation - Volume 22, Issue 6, June 2016, Pages 1102-1107
Journal: Biology of Blood and Marrow Transplantation - Volume 22, Issue 6, June 2016, Pages 1102-1107
نویسندگان
Yayoi Matsumura-Kimoto, Yoshihiro Inamoto, Kinuko Tajima, Akihisa Kawajiri, Takashi Tanaka, Tsuneaki Hirakawa, Kazuko Ino, Yu Asao, Hiroyuki Tamogami, Chika Kono, Wataru Takeda, Keiji Okinaka, Shigeo Fuji, Saiko Kurosawa, Sung-Won Kim, Ryuji Tanosaki,