Gender and Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation

- One third of HLA-identical sibling donor transplant recipients never ever develop any graft-versus-host disease
- This rate of no graft-versus-host disease is significantly higher with male donors in female recipients
- Factors associated with no graft-versus-host disease should become a target of precision medicine
- Prediction of no graft-versus-host disease could become a decision-guiding tool for early transplantations
- Such an approach could spare immunosuppression, improve survival, and reduce costs