کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8437601 | 1546871 | 2018 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression
ترجمه فارسی عنوان
التهاب شبکیه ناشی از آلرژی کونژوکتیویت باعث پیشرفت نزدیک بینی می شود
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کلمات کلیدی
نزدیک بینی التهاب آسم، درماتیت آتوپیک، رینیت آلرژیک، آلرژیک ملانژیتی مطالعات مبتنی بر جمعیت،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
Myopia is a highly prevalent eye disease. There is limited information suggesting a relationship between myopia and inflammation. We found children with allergic conjunctivitis (AC) had the highest adjusted odds ratio (1.75, 95% confidence interval [CI], 1.72-1.77) for myopia among the four allergic diseases. A cohort study was conducted and confirmed that children with AC had a higher incidence and subsequent risk of myopia (hazard ratio 2.35, 95%CI 2.29-2.40) compared to those without AC. Lower refractive error and longer axial length were observed in an AC animal model. Myopia progression was enhanced by tumor necrosis factor (TNF)-α or interleukin (IL)-6 administration, two cytokines secreted by mast cell degranulation. The TNF-α or IL-6 weakened the tight junction formed by corneal epithelial (CEP) cells and inflammatory cytokines across the layer of CEP cells, which increased the levels of TNF-α, IL-6, and IL-8 secreted by retinal pigment epithelial cells. The expression levels of TNF-α, IL-6, IL-8, monocyte chemoattractant protein-1, and nuclear factor kappa B were up-regulated in eyes with AC, whereas IL-10 and the inhibitor of kappa B were down-regulated. In conclusion, the experimental findings in mice corroborate the epidemiological data showing that allergic inflammation influences the development of myopia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: EBioMedicine - Volume 28, February 2018, Pages 274-286
Journal: EBioMedicine - Volume 28, February 2018, Pages 274-286
نویسندگان
Chang-Ching Wei, Yung-Jen Kung, Chih Sheng Chen, Ching-Yao Chang, Chao-Jen Lin, Peng-Tai Tien, Hsing-Yi Chang, Hsuan-Ju Chen, Yong-San Huang, Hui-Ju Lin, Lei Wan,