کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8438267 | 1401521 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer
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کلمات کلیدی
BCATERK27HCBCKABCKDHA27-Hydroxycholesterol - 27-هیدروکسی کلسترولMAPK - MAPKbranched-chain amino acids - آمینو اسیدهای زنجیرهای منشعب شدهBCAA - بی سی ای ایTumorigenesis - تومورزاییColorectal cancer - سرطان روده بزرگPhenylbutyrate - فنیل بوتیرتMEK - مجاهدین خلقmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenCRC - کد افزونگی دورهای extracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer](/preview/png/8438267.png)
چکیده انگلیسی
Branched-chain amino acids catabolism plays an important role in human cancers. Colorectal cancer is the third most commonly diagnosed cancer in males and the second in females, and the new global incidence is over 1.2 million cases. The branched-chain α-keto acid dehydrogenase kinase (BCKDK) is a rate-limiting enzyme in branched-chain amino acids catabolism, which plays an important role in many serious human diseases. Here we investigated that abnormal branched-chain amino acids catabolism in colorectal cancer is a result of the disease process, with no role in disease initiation; BCKDK is widely expressed in colorectal cancer patients, and those patients that express higher levels of BCKDK have shorter survival times than those with lower levels; BCKDK promotes cell transformation or colorectal cancer ex vivo or in vivo. Mechanistically, BCKDK promotes colorectal cancer by enhancing the MAPK signaling pathway through direct MEK phosphorylation, rather than by branched-chain amino acids catabolism. And the process above could be inhibited by a BCKDK inhibitor, phenyl butyrate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: EBioMedicine - Volume 20, June 2017, Pages 50-60
Journal: EBioMedicine - Volume 20, June 2017, Pages 50-60
نویسندگان
Peipei Xue, Fanfan Zeng, Qiuhong Duan, Juanjuan Xiao, Lin Liu, Ping Yuan, Linni Fan, Huimin Sun, Olesya S. Malyarenko, Hui Lu, Ruijuan Xiu, Shaoqing Liu, Chen Shao, Jianmin Zhang, Wei Yan, Zhe Wang, Jianyong Zheng, Feng Zhu,