کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8438719 1401526 2017 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of an atypical etiological head and neck squamous carcinoma subtype featuring the CpG island methylator phenotype
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Identification of an atypical etiological head and neck squamous carcinoma subtype featuring the CpG island methylator phenotype
چکیده انگلیسی
Further distinguishing features of this 'CIMP-Atypical' subtype include an antiviral gene expression profile associated with pro-inflammatory M1 macrophages and CD8+ T cell infiltration, CASP8 mutations, and a well-differentiated state corresponding to normal SOX2 copy number and SOX2OT hypermethylation. We developed a gene expression classifier for the CIMP-Atypical subtype that could classify atypical disease features in two independent patient cohorts, demonstrating the reproducibility of this subtype. Taken together, these findings provide unprecedented evidence that atypical HNSCC is molecularly distinct, and postulates the CIMP-Atypical subtype as a distinct clinical entity that may be caused by chronic inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: EBioMedicine - Volume 17, March 2017, Pages 223-236
نویسندگان
, , , , ,