کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8453297 | 1547877 | 2018 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The real-world outcomes of treating Polycythemia Vera: Physician adherence to treatment guidelines
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Therapy in Polycythemia Vera (PV), a myeloproliferative neoplasm, focuses on reducing cardiovascular (CV) risk without increasing bleeding or hematological progression. However, the real-world practice of treating PV in North America is understudied. We performed a retrospective cohort study of newly diagnosed PV (JAK2V617F mutation positive) patients in Hamilton, Canada to fill this knowledge gap. Out of 108 patients included, (nâ¯=â¯45, 41.7%) patients did not receive therapy consistent with contemporary treatment guidelines. Multivariable analysis showed increased white blood cell count at diagnosis (HR, 1.09; 95% CI, 1.04-1.14; pâ¯<â¯0.001), older age (HR, 1.15; 95% CI, 1.07-1.23; pâ¯<â¯0.001) and diabetic history (HR, 3.71; 95% CI, 1.27-10.78; pâ¯=â¯0.012) associated with greater mortality. Not receiving pharmacological treatment according to guidelines was also independently associated with increased mortality (HR, 3.12; 95% CI, 1.13-8.65; pâ¯=â¯0.029).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 70, July 2018, Pages 62-66
Journal: Leukemia Research - Volume 70, July 2018, Pages 62-66
نویسندگان
Nicholas L. Jackson Chornenki, Chatree Chai-Adisaksopha, Darryl P. Leong, Deborah M. Siegal, Christopher M. Hillis,