کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8453454 1547900 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of granulocyte colony-stimulating factor priming combined with low-dose cytarabine and homoharringtonine in higher risk myelodysplastic syndrome patients
ترجمه فارسی عنوان
اثر پرایمر فاکتور تحریک کلونی گرانولوسیت همراه با سیتارابین و هوموآرینگتونین با دوز کم در بیماران مبتلا به سندرم میلودیسپلازیس با شدت بالا
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
As sensitization of leukemia cells with granulocyte colony-stimulating factor (G-CSF) can enhance the cytotoxicity of chemotherapy in myeloid malignancies, a pilot study was conducted in order to evaluate the effect of G-CSF priming combined with low-dose chemotherapy in patients with higher risk myelodysplastic syndrome (MDS). The regimen, G-HA, consisted of cytarabine (Ara-C) 7.5 mg/m2/12 h by subcutaneous injection, days 1-14, homoharringtonine (HHT) 1.5 mg/m2/day by intravenous continuous infusion, days 1-14, and G-CSF 150 mg/m2/day by subcutaneous injection, days 0-14. 56 patients were enrolled, 34 patients (61%, 95% confidence interval: 51.44-70.56%) achieved complete remission (CR). Median duration of neutropenia was 7 days (ranging from 2 to 16 days). Grade 1-2 nonhematologic toxicities were documented, including nausea and vomiting (5%), liver function abnormality (5%), and heart function abnormality (2%). No central nervous system toxicity was found. Mortality within the first 4 weeks was 4%. The G-HA regimen is effective in remission induction for higher risk MDS patients and well tolerated due to the acceptable toxicity in maintenance therapy in the patients who cannot undergo Hematopoietic cell transplantation (HCT).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 48, September 2016, Pages 57-61
نویسندگان
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