New tool for biological dosimetry: Reevaluation and automation of the gold standard method following telomere and centromere staining

- We have applied telomere and centromere (TC) staining to the scoring of dicentrics.
- TC staining renders the scoring of dicentrics more rapid and robust.
- TC staining allows the scoring of not only dicentrics but all chromosomal anomalies.
- TC staining has led to a reevaluation of the radiation dose-response curve.
- TC staining allows automation of the scoring of chromosomal aberations.
- Automated scoring of dicentrics after TC staining was as efficient as manual scoring.