کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8455786 | 1548329 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
High levels of γ-H2AX foci and cell membrane oxidation in adolescents with type 1 diabetes
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: High levels of γ-H2AX foci and cell membrane oxidation in adolescents with type 1 diabetes High levels of γ-H2AX foci and cell membrane oxidation in adolescents with type 1 diabetes](/preview/png/8455786.png)
چکیده انگلیسی
In the present study, we confirmed the role that oxidative stress plays in the disease damaging lipids of cell membrane and, most importantly, causing genomic damage in circulating white blood cells of affected adolescents. This also indicates that oxidative stress can affect several tissues in the body. However, although the observed DNA damage is a clear indication that the proper DNA repair mechanisms are activated, the risk for young T1DM subjects of developing not only cardiovascular complications but also some type of cancer cannot be ruled out. In this view, females, probably due to hormonal imbalance typical of adolescence, might represent a more susceptible population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 770, December 2014, Pages 128-135
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 770, December 2014, Pages 128-135
نویسندگان
Caterina Giovannini, Simona Piaggi, Giovanni Federico, Roberto Scarpato,