Powering mammalian genetic screens with mouse haploid embryonic stem cells

► Mouse haploid embryonic stem cells (ESCs) can be derived from parthenogenetic or androgenetic embryos. ► Mouse haploid ESCs share most of the same pluripotency characteristics with diploid ESCs. ► Mouse haploid ESCs can be used for forward genetic screening, reverse genetic screening, and homozygous mutant animal production.