Defect of Dpb2p, a noncatalytic subunit of DNA polymerase ɛ, promotes error prone replication of undamaged chromosomal DNA in Saccharomyces cerevisiae

► Dpb2p, a noncatalytic subunit of Pol ɛ, influences the fidelity of DNA replication. ► Inactivation of DNA Pol ζ in dpb2 strains decreases the mutation rates by 30-50%. ► Mutated Dpb2p variants influence DNA Pol ɛ insertion fidelity.