Role of Rad52 in fractionated irradiation induced signaling in A549 lung adenocarcinoma cells

► Fractionated irradiation induces radioresistance in lung carcinoma A549 cells. ► Fractionated irradiation up-regulates survival/repair pathways in cancer cells. ► The reason for radioresistance could be the activation of DNA repair pathways. ► Rad52 gene is an important factor modulating radioresistance in A549 cells.