Flanking nucleotide specificity for DNA mismatch repair-deficient frameshifts within Activin Receptor 2 (ACVR2)

► The primary sequence surrounding DNA microsatellites helps determine microsatellite mutability. ► Flanking nucleotides around coding ACVR2 microsatellites alter heteroduplex DNA formation. ► Frameshift mutation is determined by individual nucleotides surrounding ACVR2 microsatellites.