کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8456158 | 1548400 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The relationship between 8-oxo-7,8-dihydro-2â²-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The relationship between 8-oxo-7,8-dihydro-2â²-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas The relationship between 8-oxo-7,8-dihydro-2â²-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas](/preview/png/8456158.png)
چکیده انگلیسی
Our work provides the first in vivo evidence suggesting that increased levels of 8-oxodG in DNA may lead to carcinogenesis not only via mispair/mutagenic potential of the modified base but also through its ability to influence gene expression by affecting DNA methylation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 640, Issues 1â2, 2 April 2008, Pages 170-173
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 640, Issues 1â2, 2 April 2008, Pages 170-173
نویسندگان
Jolanta Guz, Marek Foksinski, Agnieszka Siomek, Daniel Gackowski, Rafal Rozalski, Tomasz Dziaman, Anna Szpila, Ryszard Olinski,