Chromosome aberrations induced by the Auger electron emitter 125I

125I-UdR has a very strong genotoxic capacity in human PBL, even at 0.2 Gy. Efficiently labelled cells displaying a prolonged cell cycle compared to moderately labelled cells and cell death contribute substantially to the desynchronisation of the cell cycle. Our data, showing for the first time, that one 125I-decay induces ∼ 0.2 chromatid aberrations, are in very good accordance to DSB data, stating that ∼0.26 DSB are induced per decay, indicating that approximately every DSB is converted into a chromatid aberration.