کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8456410 | 1548582 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of a repeated-dose liver micronucleus assay with 2,6-dinitrotoluene using young adult rats
ترجمه فارسی عنوان
بررسی دوز مکرر دوز کبدی میکرونوکلئوس با 2،6-دیینیتروتوولین با استفاده از موش های صحرایی جوان
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
As part of a collaborative study by the Mammalian Mutagenicity Study Group of the Environmental Mutagen Society of Japan, we examined micronucleus induction in hepatocytes following oral administration of 2,6-dinitrotoluene (2,6-DNT) at 30, 40, and 50Â mg/kg/day for 14 days or at 20, 30, and 40Â mg/kg/day for 28 days to young adult male rats. This compound is known to be a rat liver carcinogen. The formation of micronucleated hepatocytes was confirmed to be dose-dependent with statistically significant increases observed in both treatments. In contrast, no statistically significant changes in the percentage of micronucleated immature erythrocytes were observed in any dose group in the bone marrow micronucleus assay. These results indicated that the repeated-dose liver micronucleus assay has the potential to detect genotoxic hepatocarcinogens and can be integrated into general toxicological studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volumes 780â781, March 2015, Pages 46-50
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volumes 780â781, March 2015, Pages 46-50
نویسندگان
Tadashi Imamura, Akiko Koeda, Kiyoshi Morimoto, Hirofumi Hatakeyama, Hiroshi Suzuki, Yumi Wako, Kazufumi Kawasako, Koji Otabe, Shin-ichi Sato,