کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8456425 | 1548582 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The 14-day repeated dose liver micronucleus test with methapyrilene hydrochloride using young adult rats
ترجمه فارسی عنوان
آزمایش ادرار میکرونوکلئیک کبدی با دوز مکرر 14 روزه با متپایریل هیدروکلراید با استفاده از موش های صحرایی جوان
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
The repeated dose liver micronucleus (RDLMN) assay using young adult rats has the potential to detect genotoxic hepatocarcinogens that can be integrated into a general toxicity study. The assay methods were thoroughly validated by 19 Japanese facilities. Methapyrilene hydrochloride (MP), known to be a non-genotoxic hepatocarcinogen, was examined in the present study. MP was dosed orally at 10, 30 and 100Â mg/kg/day to 6-week-old male Crl:CD (SD) rats daily for 14 days. Treatment with MP resulted in an increase in micronucleated hepatocytes (MNHEPs) with a dosage of only 100Â mg/kg/day. At this dose level, cytotoxicity followed by regenerative cell growth was noted in the liver. These findings suggest that MP may induce clastogenic effects indirectly on the liver or hepatotoxicity of MP followed by regeneration may cause increase in spontaneous incidence of MNHEPs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volumes 780â781, March 2015, Pages 123-127
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volumes 780â781, March 2015, Pages 123-127
نویسندگان
Kenji Inoue, Akimu Ochi, Akira Koda, Yumi Wako, Kazufumi Kawasako, Takaaki Doi,