Induction of sister chromatid exchange by acrylamide and glycidamide in human lymphocytes: Role of polymorphisms in detoxification and DNA-repair genes in the genotoxicity of glycidamide

► DNA damage induced by AA and GA in cultured human lymphocytes was evaluated. ► AA only slightly induced SCEs, especially for the highest concentration tested. ► GA markedly induced SCEs in a dose-response manner up to 750 μM. ► Associations between the induction of SCEs with GSTP1 and GSTA2 polymorphisms are suggested.