کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8457524 1548810 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cerebral vasomotor reactivity in neurodegenerative diseases
ترجمه فارسی عنوان
واکنش پذیری واسوموتور مغزی در بیماری های نورودنراتیو
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Small-caliber cerebral vessels change their diameters in response to alterations of key metabolite concentrations such as carbon dioxide or oxygen. This phenomenon, termed the cerebral vasomotor reactivity (CVMR), is the basis for blood flow regulation in the brain in accordance with its metabolic status. Typically, CVMR is determined as the amount of change in cerebral blood flow in response to a vasodilating stimulus, which can be measured by various neuroimaging methods or by transcranial Doppler. It has been shown that CVMR is impaired in cerebrovascular diseases, but there is also evidence of a similar dysfunction in neurodegenerative disorders. Here, we review studies that have investigated CVMR in the common neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and multiple sclerosis. Moreover, we discuss potential neurodegenerative mechanisms responsible for the impairment of CVMR.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurologia i Neurochirurgia Polska - Volume 50, Issue 6, November–December 2016, Pages 455-462
نویسندگان
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