Cyclotron production of 99mTc

Intensive efforts were undertaken during the last few decades for the separation of cyclotron-produced 99mTc from 99Mo and new papers have been published on this topic since the last review [1]. In the future the cyclotron-based methods can replace reactor-based technology in producing this medical radioisotope and the nuclear reaction 100Mo(p,2n)99mTc appears to be the most worthwhile approach. New ways of producing of 99mTc require efficient separation methods. Several strategies for separation of 99mTc from 99Mo have been already developed. The advantages, disadvantages and technical challenges toward application potential of investigated methods to separate 99mTc from irradiated 100Mo target are discussed. These methods include column chromatography, solvent extraction, chemical precipitation and thermochromatography.