کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8483613 | 1551566 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Speed Index in the Racing Quarter Horse: A Genome-wide Association Study
ترجمه فارسی عنوان
شاخص سرعت در مسابقه چهارم اسب: مطالعه انجمن ژنوم
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
The racing line of Quarter Horses is characterized by great sprinting speed over short distances on straight tracks. To perform selection on racing horses, the speed index (SI) and conformation traits are often used. A genome-wide association study (GWAS) on 112 racing Quarter Horses was performed for the SI trait, and markers and genes associated were reported. The GWAS was carried out using the Qxpak.5 software and the genotyping data obtained from the Equine SNP50 BeadChip. A total of eight significant single-nucleotide polymorphisms (SNPs) (P < .0001; Q = 0.25) distributed on Equus caballus autosomal chromosomes 2, 4, 10, 18, and 27 were found and served as markers for genomic regions mined for candidate genes associated with SI. For candidate gene, annotation was considered 100Â kb windows upstream and downstream to each important SNP. The highlighted genes were GRM8, GRIK2, NEB, ANK1, and KAT6A because their function could be related to racing performance. Future studies should consider a validation study with an independent population, and sequencing of these candidate genes should be done to identify causal alleles.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Equine Veterinary Science - Volume 34, Issues 11â12, NovemberâDecember 2014, Pages 1263-1268
Journal: Journal of Equine Veterinary Science - Volume 34, Issues 11â12, NovemberâDecember 2014, Pages 1263-1268
نویسندگان
Camila Tangari MD, Marina R.S. PhD, Michel Marques MD, Laércio R. PhD, Matthew PhD, Stephen S. PhD, Guilherme L. MD, Luis Artur Loyola PhD, Rogério Abdallah PhD,