کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8483643 | 1551566 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Proton-Pump Inhibitor Modifies the Concentration of Digestion Biomarkers in Healthy Horses
ترجمه فارسی عنوان
بازدارنده پروتون پمپ تغییر غلظت بیومارکرهای گوارش در اسب های سالم
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کلمات کلیدی
هضم، چربی امپرازول، منیزیم، تری گلیسرید،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
To determine the concentration of various blood biomarkers associated with digestion in healthy horses treated with different doses of omeprazole (OMPZ), four Arabian horses without gastric ulcers were selected and distributed in one factorial with four oral treatments (Control; OMPZBOLUS; OMPZ4mg/kg; OMPZ1mg/kg). Control did not receive any treatment. OMPZBOLUS were given 4Â mg/kg of omeprazole in a single dose on the day before blood sampling. In the OMPZ4mg/kg and OMPZ1mg/kg treatments, horses were treated over 11Â days. All treatments were performed 16Â hours before morning feeding. The “washout” period was 21Â days between rounds. After an overnight fasting period, blood samples were collected from all animals (T1), after which the animals received supplementation, and blood samples were collected after 30Â minutes (T2), 1.0Â hours (T3), 1.5Â hours (T4), 2.0Â hours (T5), 3.0Â hours (T6), 4.0Â hours (T7), 5.0Â hours (T8), 6.0Â hours (T9), and 7.0Â hours (T10). Blood samples were analyzed for total plasma protein (TPP), glucose, urea, creatinine, uric acid, cholesterol, triglycerides, calcium, phosphorus, and magnesium. The results showed differences between treatments for urea, cholesterol, uric acid; between phases for glucose; and between phase and treatment for creatinine, triglycerides, phosphorus, and magnesium; however, there was no difference for TPP and calcium between treatment and between phases. Oral administration of OMPZ in healthy equines interfered with the metabolism of digestion biomarkers of lipid, mineral, and protein metabolism, although the animals were treated for a maximum of 11Â days. Horses treated with a proton-pump inhibitor need to be evaluated regularly to avoid significant modification in their metabolic parameters.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Equine Veterinary Science - Volume 34, Issues 11â12, NovemberâDecember 2014, Pages 1318-1323
Journal: Journal of Equine Veterinary Science - Volume 34, Issues 11â12, NovemberâDecember 2014, Pages 1318-1323
نویسندگان
Stephânia Katurchi Mendes BVSc, MSc, Tito Alves BVSc, MSc, Thaisa de Lima BSc, José Mário Girão BVSc, MSc, PhD, Helena EmÃlia Cavalcanti da Costa Cordeiro BAniSc, MSc, PhD, Hélio Cordeiro BVSc, MSc, PhD,