کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8497272 | 1553176 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Early handling effect on female rat spatial and non-spatial learning and memory
ترجمه فارسی عنوان
اثر زودهنگام در یادگیری و حافظه فضایی و غیر فضایی موش ماده
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کلمات کلیدی
دست زدن به زودیاک، حافظه اعلام شده حافظه کاری، انعطاف پذیری رفتاری مراقبت از مادر، موش صحرایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
This study aims at providing an insight into early handling procedures on learning and memory performance in adult female rats. Early handling procedures were started on post-natal day 2 until 21, and consisted in 15Â min, daily separations of the dams from their litters. Assessment of declarative memory was carried out in the novel-object recognition task; spatial learning, reference- and working memory were evaluated in the Morris water maze (MWM). Our results indicate that early handling induced an enhancement in: (1) declarative memory, in the object recognition task, both at 1Â h and 24Â h intervals; (2) reference memory in the probe test and working memory and behavioral flexibility in the “single-trial and four-trial place learning paradigm” of the MWM. Short-term separation by increasing maternal care causes a dampening in HPA axis response in the pups. A modulated activation of the stress response may help to protect brain structures, involved in cognitive function. In conclusion, this study shows the long-term effects of a brief maternal separation in enhancing object recognition-, spatial reference- and working memory in female rats, remarking the impact of early environmental experiences and the consequent maternal care on the behavioral adaptive mechanisms in adulthood.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Processes - Volume 103, March 2014, Pages 9-16
Journal: Behavioural Processes - Volume 103, March 2014, Pages 9-16
نویسندگان
Fulvio Plescia, Rosa A.M. Marino, Michele Navarra, Giuditta Gambino, Anna Brancato, Pierangelo Sardo, Carla Cannizzaro,