کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8504689 | 1554984 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of Marek's disease vaccines on interferon and toll like receptors when administered in ovo
ترجمه فارسی عنوان
اثر واکسن های بیماری مارک بر اینترفرون و عوارض جانبی مانند گیرنده ها در زمان تخمک گذاری
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
The effect of two Marek's disease (MD) vaccines on the chicken embryo immune responses were evaluated. Transcription of interferon (IFN-α, IFN-β, IFN-λ, and IFN-γ) and interferon-I receptors (IFN-AR1 and IFN-AR2), as well as transcription of toll like receptors (TLR-3, TLR-7, and TLR-21) were evaluated in the bursa, thymus, spleen and lung of 1-day-old chickens that had been vaccinated with HVT, CVI988, or sham inoculated at embryonic day 18 (ED18). Each vaccine had a unique effect on the transcription of the evaluated genes and it differs among tissues. HVT increased IFN-γ and TLR-3 transcripts in the spleen and lung and IFN-β in the bursa. The immune responses elicited by CVI988 differed from that observed in the HVT inoculated group. CVI988 downregulated several of the studied genes and only upregulated IFN-β and TLR-21 in spleen. Differences in vaccine replication (53% of spleens and lungs of HVT-vaccinated embryos but only 22% of spleens of CVI988-vaccinated embryos had detectable viral gB transcripts) were detected. Previously, we have shown that intra-amniotic vaccination at ED18 with HVT but not with CVI988 rendered chickens more immunocompetent at hatch. The role of increased transcription of TLR-3 and IFN-γ in such positive effect warrant further investigations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 201, July 2018, Pages 62-66
Journal: Veterinary Immunology and Immunopathology - Volume 201, July 2018, Pages 62-66
نویسندگان
Isabel M. Gimeno, Ayanna Glaize, Aneg L. Cortes,