کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8504711 | 1554986 | 2018 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The use of serological tests in combination with the intradermal tuberculin test maximizes the detection of tuberculosis infected goats
ترجمه فارسی عنوان
استفاده از آزمایش های سرولوژیکی در ترکیب با آزمایشات داخل سلولی توبرکولین، تشخیص بز های آلوده به سل را به حداکثر می رساند
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کلمات کلیدی
بز بیماری سل، تشخیص، سرولوژی، اثر تقویت کننده،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
The diagnosis of tuberculosis (TB) in goats is based mainly on the single and comparative intradermal tuberculin (SIT and CIT) tests and, exceptionally, on the interferon-gamma (IFN-γ) assay, however they are not perfect in terms of sensitivity and specificity. Nevertheless, various serological assays that provide a potential cost-effective approach for the control of TB are also available or under development, and a variety of results have been reported regarding the ability of these tests to detect infected animals, particularly in the early stages of infection. In the present study, SIT/CIT and IFN-γ tests and three different serological assays were evaluated during two consecutive herd testing events in a recently infected caprine herd (nâ¯=â¯447) with a high prevalence of infection in order to evaluate their performance and provide field data with which to improve the TB control programs in this species. The proportion of infected animals that tested positive among all the infected goats (T+/I+ value) in the last herd testing event ranged from 26.2% (IC95%; 19.3-34.5) to 85.7% (IC95%; 78.5-90.7) using cell-based diagnostic tests. The SIT/SCIT tests detected more infected goats than the IFN-γ test, regardless of the interpretation criteria. The T+/I+ value of serology was 83.2 (IC95%; 75.2-89), although it increased significantly (Pâ¯<â¯0.05) when using samples collected 15â¯days after the intradermal test (100%, IC95%; 97-100). In general, a parallel interpretation of intradermal tests with serology maximized the detection of infected goats. These results demonstrate that serological tests are valuable diagnostic tools to maximize the detection of TB infected goats, even in recent outbreaks, accelerating the eradication process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 199, May 2018, Pages 43-52
Journal: Veterinary Immunology and Immunopathology - Volume 199, May 2018, Pages 43-52
نویسندگان
Javier Bezos, Álvaro Roy, José Antonio Infantes-Lorenzo, Isabel González, Ángel Venteo, Beatriz Romero, Anna Grau, Olga MÃnguez, Lucas DomÃnguez, LucÃa de Juan,