کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8626347 1568536 2018 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Embryonic lethality in mice due to carnitine transporter OCTN2 defect and placental carnitine deficiency
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Embryonic lethality in mice due to carnitine transporter OCTN2 defect and placental carnitine deficiency
چکیده انگلیسی
l-Carnitine plays a crucial role in uptake and subsequent β-oxidation of long-chain fatty acids in the mitochondria. Placental trophoblast cells oxidize long-chain fatty acids for energy production. Here we present data showing that l-carnitine deficiency due to a defect in the carnitine transporter OCTN2 (SLC22A5) in a mouse model leads to embryonic lethality. Placental levels of l-carnitine are reduced to <10% of normal and deficiency of l-carnitine is associated with markedly reduced expression of several growth factors and transforming growth factor β (TGF-β) genes. This report links for the first time reduced l-carnitine levels in the placenta to embryonic lethality.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 69, September 2018, Pages 71-73
نویسندگان
, , , ,