کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8626423 1568542 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Utility of DNA methylation to assess placental health
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Utility of DNA methylation to assess placental health
چکیده انگلیسی
DNA methylation (DNAm), a mitotically stable epigenetic mark, can influence as well as reflect gene expression. DNAm has been gaining interest for use as a biomarker for many conditions including placental insufficiency, specifically preeclampsia (PE) and intrauterine growth restriction (IUGR). Additionally, DNAm may retain a “memory” of earlier in utero exposures and hence provide insight into pathogeneses occurring earlier in gestation. This review will discuss the placental DNA methylome, the uses of DNAm to assess placental health, and considerations and limitations to understand in epigenome-wide association studies (EWAS).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 64, Supplement 1, April 2018, Pages S23-S28
نویسندگان
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