کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8627518 1568663 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polyethylene particles inserted over calvarium induce cancellous bone loss in femur in female mice
ترجمه فارسی عنوان
ذرات پلی اتیلن بیش از کلواریوم باعث ایجاد ضایعه استخوانی در استخوان ران در موش های ماده می شوند
کلمات کلیدی
استئوآرتریت تحلیل استخوان، تشکیل استخوان، پوکی استخوان،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Focal bone resorption (osteolysis) induced by wear particles contributes to long-term orthopedic joint failure. However, the impact of focal osteolysis on remote skeletal sites has received less attention. The goal of this study was to determine the effects of polyethylene particles placed over calvaria on representative axial and appendicular skeletal sites in female mice. Because recent work has identified housing temperature as an important biological variable in mice, response to particle treatment was measured in animals housed at room (22 °C) and thermoneutral (32 °C) temperature. Osteolysis was evident in skeletal tissue adjacent to particle insertion. In addition, cancellous bone loss was observed in distal femur metaphysis. The bone loss was associated with lower osteoblast-lined perimeter and lower mineralizing perimeter in distal femur, lower osteocalcin gene expression in tibia, and lower serum osteocalcin, suggesting the response was due, at least in part, to reduced bone formation. Mild cold stress induced by sub-thermoneutral housing resulted in cancellous bone loss in distal femur and lumbar vertebra but did not influence skeletal response to particles. In summary, the results indicate that focal inflammation induced by polyethylene particles has the potential to result in systemic bone loss. This is significant because bone loss is a risk factor for fracture.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone Reports - Volume 9, December 2018, Pages 84-92
نویسندگان
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