کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8627656 | 1568664 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of the long-term skeletal effect induced by teratogen 5-aza-2â²deoxycytidine on offspring of high (C3H/HeJ) and low (C57BL/6J) bone mass phenotype mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The main observation of this study is that 5-AZA-induced loss of bone length was registered in 12-mo-old C57 and C3H males. As expected, we did not find differences in the 3rd lumbar vertebra since in-utero exposure to 5-AZA was shown to affect the limb buds but not the axial skeleton. Trajectory of changes in bone phenotypes from ages 3â¯mo through 6â¯mo to 12â¯mo was also compared; 5-AZA-exposed C57 males had consistently lower femoral length and trabecular BMD than age-matched controls. In summary, by characterizing teratogen-exposed C57 and C3H mice, we further confirmed that the adaptive response to antenatal insults continue into mid-life of the mice as well as there is a sex-specificity of these responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone Reports - Volume 8, June 2018, Pages 239-243
Journal: Bone Reports - Volume 8, June 2018, Pages 239-243
نویسندگان
Deepak Kumar Khajuria, Maria Raygorodskaya, Eugene Kobyliansky, Yankel Gabet, Sahar Hiram Bab, Chen Shochat, Arkady Torchinsky, David Karasik,