کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8644457 | 1569760 | 2018 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Specific enzyme functionalities of Fusarium oxysporum compared to host plants
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کلمات کلیدی
CATHGTUDP-GlcNAcHCCsHMMDcPSAp4AUDP-N-acetylglucosamineIDOL-TRPN-SmaseCWDEsIC50CDP-choline - CDP-کولینl-Tryptophan - l-تریپتوفانl-methionine - L-متیونینspinal muscular atrophy - آتروفی عضلانی نخاعیArabidopsis - آرابیدوپسیس یا رشادیHorizontal gene transfer - انتقال ژن افقیMolecular targets - اهداف مولکولیindoleamine 2,3-dioxygenase - ایندولامین 2،3-دیوکسژیگنازDiadenosine tetraphosphate - تتراپسفات دیادنوزینKEGG یا Kyoto Encyclopedia of Genes and Genomes - دایرة المعارف ژن ها و ژنوم کیوتو SMA - دبیرستانFusariosis - فوزاریوزHidden Markov model - مدل پنهان مارکوف NAD - نادانhalf maximal inhibitory concentration - نیمه حداکثر غلظت مهاریnicotinamide adenine dinucleotide - نیکوتین آمید adenine dinucleotideCarnitine acetyltransferase - کارنیتین استیل ترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The genus Fusarium contains some of the most studied and important species of plant pathogens that economically affect world agriculture and horticulture. Fusarium spp. are ubiquitous fungi widely distributed in soil, plants as well as in different organic substrates and are also considered as opportunistic human pathogens. The identification of specific enzymes essential to the metabolism of these fungi is expected to provide molecular targets to control the diseases they induce to their hosts. Through applications of traditional techniques of sequence homology comparison by similarity search and Markov modeling, this report describes the characterization of enzymatic functionalities associated to protein targets that could be considered for the control of root rots induced by Fusarium oxysporum. From the analysis of 318 F. graminearum enzymes, we retrieved 30 enzymes that are specific of F. oxysporum compared to 15 species of host plants. By comparing these 30 specific enzymes of F. oxysporum with the genome of Arabidopsis thaliana, Brassica rapa, Glycine max, Jatropha curcas and Ricinus communis, we found 7 key specific enzymes whose inhibition is expected to affect significantly the development of the fungus and 5 specific enzymes that were considered here to be secondary because they are inserted in pathways with alternative routes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 676, 15 November 2018, Pages 219-226
Journal: Gene - Volume 676, 15 November 2018, Pages 219-226
نویسندگان
Larissa Catharina, Nicolas Carels,