کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8645851 | 1569794 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparative transcriptomic characterization of a new mib mutant allele, mibnn2002, in zebrafish
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
MIBIPAmind bomb - بمب ذهنBioinformatics analysis - تجزیه و تحلیل بیوانفورماتیکIngenuity Pathway Analysis - تجزیه و تحلیل راه IngenuityNext generation sequencing - توالی نسل بعدیDAVID - دیویدthe Database for Annotation, Visualization and Integrated Discovery - پایگاه داده برای علامت گذاری، تجسم و کشف مجتمعZebrafish - گورخرماهی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Comparative transcriptomic characterization of a new mib mutant allele, mibnn2002, in zebrafish Comparative transcriptomic characterization of a new mib mutant allele, mibnn2002, in zebrafish](/preview/png/8645851.png)
چکیده انگلیسی
mibnn2002, identified from an allele screen, shows early segmentation defect and severe cell death phenotypes, which are different from those of other described mib mutant alleles. We have previously reported its defects in somitogenesis and identified its origin of mutation, a large deletion in LG2. The report here is a continuous study, where we applied the bioinformatics analysis to profile the genetic background of mibnn2002 mutants. By comparing the transcriptomic data of mibnn2002 mutants with those of AB wild-type, a total of 1945 differentially expressed genes were identified, including 685 up- and 1260 down-regulated genes. The Database for Annotation, Visualization and Integrated Discovery (DAVID) analysis and Ingenuity Pathway Analysis (IPA) identified the enriched pathways and their related biological functions. Our data further demonstrated that the defects in the somitogenesis were related to the down-regulated segmentation genes, such as foxc1a, smyhc1, myod1 and mylpfa.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 642, 5 February 2018, Pages 51-57
Journal: Gene - Volume 642, 5 February 2018, Pages 51-57
نویسندگان
Keng Po Lai, Jing-Woei Li, Chia-Hao Hsu, May-Su You, Ting-Fung Chan, William Ka Fai Tse, Yun-Jin Jiang,