کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8650820 | 1571280 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hypoglossal nerve stimulation in a pre-clinical anesthetized rabbit model relevant to OSA
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Hypoglossal nerve stimulation in a pre-clinical anesthetized rabbit model relevant to OSA Hypoglossal nerve stimulation in a pre-clinical anesthetized rabbit model relevant to OSA](/preview/png/8650820.png)
چکیده انگلیسی
We tested the functional effects of hypoglossal (CNXII) stimulation in the anesthetized rabbit before and after injections of saline into the tongue base to obstruct the airway. Data (nâ¯=â¯6) show little or no effect of CN XII trunk stimulation; however, medial branch stimulation (20-100â¯Hz; 50-500â¯Î¼s pulse width, and incremental increases from 10â¯Î¼A) reduced upper airway resistance. Medial branch stimulation was less effective in reducing resistance than anterior advancement of the hyoid. Endoscopic viewing (n-3) of the retropalate showed this region as the narrowest and dynamically changed by anterior hyoid displacement, with less evident effects than CNXII stimulation. We conclude that under these conditions CNXII medial branch stimulation reduces airway resistance, especially after induced obstruction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 250, April 2018, Pages 31-38
Journal: Respiratory Physiology & Neurobiology - Volume 250, April 2018, Pages 31-38
نویسندگان
Girriso F. Benderro, Jenniffer Gamble, Matthew A. Schiefer, Jonathan Z. Baskin, Yeritza Hernandez, Kingman P. Strohl,