کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8959398 | 1646313 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibitory effect of blue honeysuckle extract on high-fat-diet-induced fatty liver in mice
ترجمه فارسی عنوان
اثر مهاری عصاره عصاره آفتابگردان بر روی کبد چرب باعث القاء چربی در رژیم غذایی موش
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کلمات کلیدی
اسطوخودوس پلی فنل، کبد چرب، پراکسیداسیون لیپید، آنتی اکسیدان،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
Blue honeysuckle is rich in polyphenols, and recently receiving attention because of its potential antioxidant and anti-inflammatory properties. Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease that develops hepatic inflammation and metabolic syndrome. The present study aims to study the effect of blue honeysuckle extract (BHE) on fat deposition and hepatic lipid peroxidation in a high-fat-diet (HFD)-induced mouse model. Mice were fed a normal diet (ND) or a HFD containing 0.5% or 1% of BHE or not for 45 d. Liver sections were stained by hematoxylin-eosin staining. Serum lipids were measured by a clinical analyzer. Insulin was examined by ELISA, and hepatic proteins were detected by Western blotting. Dietary supplementation of BHE dose-dependently suppressed HFD-induced obesity and hepatic fat deposition. Moreover, BHE improved glucose metabolism by increasing insulin sensitivity and attenuated oxidative stress potentially by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Animal Nutrition - Volume 4, Issue 3, September 2018, Pages 288-293
Journal: Animal Nutrition - Volume 4, Issue 3, September 2018, Pages 288-293
نویسندگان
Ming Liu, Jijun Tan, Ziyu He, Xi He, De-Xing Hou, Jianhua He, Shusong Wu,