کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8961231 | 1646477 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sonochemical fabrication of reduction-responsive magnetic starch-based microcapsules
ترجمه فارسی عنوان
ساخت سلولهای شیمیایی میکروکپسولهای مبتنی بر نشاسته مغناطیسی کاهش دهنده پاسخ
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
چکیده انگلیسی
In this work, a novel, biocompatible, non-immunogenic and reductive-responsive magnetic starch-based microcapsules (RMSMCs) were designed and fabricated successfully via a facile sonochemical method for targeted delivery and triggered release of hydrophobic drugs. TEM image indicated that oleic acid (OA) modified Fe3O4 nanoparticles (OA-Fe3O4 NPs) were encapsulated into RMSMCs. The obtained RMSMCs were endowed with magnetism for drug targeted delivery because that the superparamagnetic OA-Fe3O4 NPs were encapsulated into RMSMCs. Moreover, Coumarin 6 (C6), a green fluorescent dye, was used as a model hydrophobic drug and loaded into RMSMCs. As drug carriers, the obtained spherical RMSMCs with the average size of 2â¯Î¼m presented excellent reductive-responsive release ability for hydrophobic drugs. Accordingly, the obtained RMSMCs would be promising carriers for targeted delivery and triggered release of hydrophobic drugs in biomedical applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasonics Sonochemistry - Volume 49, December 2018, Pages 169-174
Journal: Ultrasonics Sonochemistry - Volume 49, December 2018, Pages 169-174
نویسندگان
Lifeng Xu, Shuangling Zhong, Chao Shi, Yuexin Sun, Shengnan Zhao, Yan Gao, Xuejun Cui,