Thyroid hormone availability and activity in avian species: A review

Two separate genes encode multiple TR isoforms, i.e. TRα and TRβ. These TRs consist of a DNA-binding domain, a ligand-binding domain, a hinge region and an amino-terminal (A/B) domain. TRs mediate their effects on transcription by binding as homodimers or heterodimers to the TH response elements (TREs). Also, unliganded TRs can bind to TREs and may so modulate transcription of target genes.