Literature-related discovery (LRD): Potential treatments for Raynaud's Phenomenon

Literature-related discovery (LRD) is the linking of two or more literature concepts that have heretofore not been linked (i.e., disjoint), in order to produce novel, interesting, plausible, and intelligible knowledge (i.e., potential discovery). The open discovery systems (ODS) component of LRD starts with a problem to be solved, and generates solutions to that problem through potential discovery. We have been using ODS LRD to identify potential treatments or preventative actions for challenging medical problems, among myriad other applications.Raynaud's Phenomenon (RP) is a condition in which small arteries, most commonly in fingers and toes, contract and cause the skin to turn pale or a patchy red to blue. We selected the subject of RP for analysis by LRD because of RP's global prevalence, and its apparent intractability to all treatments except for palliative remediation mainly through drugs or surgery. Our main goal was to identify non-drug non-surgical treatments that would 1) prevent the occurrence, or 2) reduce the progression rate, or 3) stop the progression, or 4) maybe even reverse the progression, of RP. Our secondary goal was to compare our ODS LRD approach to the RP problem with other investigators who have addressed the RP problem since Swanson's pioneering 1986 ODS LRD paper on potential RP treatments [D.R. Swanson, Fish oil, Raynauds syndrome, and undiscovered public knowledge, Perspectives in Biology and Medicine 30 (1) (1986) 7–18].We used Medline from 1965–1985 to identify potential discovery for RP. We differ from all the other authors who have addressed this problem in two major respects: we make no numerically-based filtering assumptions, and we generate substantial potential discovery (∼ 130 potential discoveries). Further, we believe our reported results are the tip of the iceberg. Much more potential discovery is possible with an adequately resourced study using the lessons learned from this demonstration study and the other demonstration studies that follow in this Special Issue.