کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8987790 | 1555137 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Innate immune traits differ between Meishan and Large White pigs
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کلمات کلیدی
PBSTNFαphorbol 12-myristate 13-acetatemAbPBMCFITCIL-1βPMA - LDC هاMonoclonal antibody - آنتی بادی مونوکلونالEDTA - اتیلن دی آمین تترا استیک اسید ethylene diamine tetraacetic acid - اتیلن دیامین تتراستیک اسیدInnate immunity - ایمنی ذاتیInterleukin-1β - اینترلوکین-1βtumour necrosis factor α - تومور نکروز عامل αPig - خوکperipheral mononuclear cells - سلول های تک هسته ای محیطیPhagocytosis - فاگوسیتوز یا بیگانهخواری fluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتMHC - مجموعه سازگاری بافتی اصلیmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریAcute phase protein - پروتئین فاز حادGenetics - ژنتیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Innate immune traits differ between Meishan and Large White pigs Innate immune traits differ between Meishan and Large White pigs](/preview/png/8987790.png)
چکیده انگلیسی
A panel of innate immune traits were compared between Meishan and Large White pigs. These pigs were of similar age and kept under the same environmental conditions to reduce non-genetically derived variation in immune traits. The animals were all apparently healthy and were not experimentally challenged with any pathogen during the study. The measures only required a small blood sample. Total white cell counts were similar between the pig breeds. However, the numbers of lymphocytes, neutrophils and monocytes differed significantly, with Meishans having higher neutrophil and monocyte counts and lower lymphocyte counts. Flow cytometric methods were used to determine quantitatively the characteristics and function of neutrophils and monocytes. Meishan neutrophils were smaller and less complex than Large White neutrophils, and phagocytosis of Escherichia coli and the ensuing oxidative burst was lower in Meishan neutrophils compared to Large White neutrophils. Monocyte phagocytosis of E. coli was significantly less than that of neutrophils in both breeds but the function of Meishan monocytes as measured by phagocytosis and tumour necrosis factor α (TNFα) release did not differ from that of Large White monocytes. Levels of acute phase proteins also differed between the breeds with a significantly higher proportion of Meishans having elevated serum amyloid A levels. However, Meishans had lower α1-acid glycoprotein levels than Large Whites and haptoglobin levels were similar. Such differences in innate immune traits may have implications in the resistance to infection by a broad range of pathogens and subsequent disease effects in these breeds. Further studies are warranted to investigate the genes underlying these traits.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 104, Issues 3â4, 8 April 2005, Pages 131-144
Journal: Veterinary Immunology and Immunopathology - Volume 104, Issues 3â4, 8 April 2005, Pages 131-144
نویسندگان
M. Clapperton, S.C. Bishop, E.J. Glass,